CovidFranceV1, Main, Exploration, bibRecord, 000663

SARS-CoV-2/COVID-19: Evolving Reality, Global Response, Knowledge Gaps, and Opportunities.

Identifieur interne : 000663 ( Main/Exploration ); précédent : 000662; suivant : 000664

SARS-CoV-2/COVID-19: Evolving Reality, Global Response, Knowledge Gaps, and Opportunities.

Auteurs : Marcin F. Osuchowski [Autriche] ; Federico Aletti [États-Unis] ; Jean-Marc Cavaillon [France] ; Stefanie B. Flohé [Allemagne] ; Evangelos J. Giamarellos-Bourboulis [Grèce] ; Markus Huber-Lang [Allemagne] ; Borna Relja [Allemagne] ; Tomasz Skirecki [Pologne] ; Andrea Szab [Hongrie] ; Marc Maegele [Allemagne]

Source :

Shock (Augusta, Ga.) [ 1540-0514 ] ; 2020.

RBID : pubmed:32433217

Descripteurs français

KwdFr :
- Betacoronavirus (MeSH), Essais cliniques comme sujet (MeSH), Humains (MeSH), Infections à coronavirus (diagnostic), Infections à coronavirus (thérapie), Infections à coronavirus (traitement médicamenteux), Infections à coronavirus (transmission), Pandémies (MeSH), Pneumopathie virale (diagnostic), Pneumopathie virale (thérapie), Pneumopathie virale (transmission), Techniques de laboratoire clinique (MeSH).
MESH :
- diagnostic : Infections à coronavirus, Pneumopathie virale.
- thérapie : Infections à coronavirus, Pneumopathie virale.
- traitement médicamenteux : Infections à coronavirus.
- transmission : Betacoronavirus, Essais cliniques comme sujet, Humains, Infections à coronavirus, Pandémies, Pneumopathie virale, Techniques de laboratoire clinique.

English descriptors

KwdEn :
- Betacoronavirus (MeSH), Clinical Laboratory Techniques (MeSH), Clinical Trials as Topic (MeSH), Coronavirus Infections (diagnosis), Coronavirus Infections (drug therapy), Coronavirus Infections (therapy), Coronavirus Infections (transmission), Humans (MeSH), Pandemics (MeSH), Pneumonia, Viral (diagnosis), Pneumonia, Viral (therapy), Pneumonia, Viral (transmission).
MESH :
- diagnosis : Coronavirus Infections, Pneumonia, Viral.
- drug therapy : Coronavirus Infections.
- therapy : Coronavirus Infections, Pneumonia, Viral.
- transmission : Coronavirus Infections, Pneumonia, Viral.
- Betacoronavirus, Clinical Laboratory Techniques, Clinical Trials as Topic, Humans, Pandemics.

Abstract

Approximately 3 billion people around the world have gone into some form of social separation to mitigate the current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. The uncontrolled influx of patients in need of emergency care has rapidly brought several national health systems to near-collapse with deadly consequences to those afflicted by Coronavirus Disease 2019 (COVID-19) and other critical diseases associated with COVID-19. Solid scientific evidence regarding SARS-CoV-2/COVID-19 remains scarce; there is an urgent need to expand our understanding of the SARS-CoV-2 pathophysiology to facilitate precise and targeted treatments. The capacity for rapid information dissemination has emerged as a double-edged sword; the existing gap of high-quality data is frequently filled by anecdotal reports, contradictory statements, and misinformation. This review addresses several important aspects unique to the SARS-CoV-2/COVID-19 pandemic highlighting the most relevant knowledge gaps and existing windows-of-opportunity. Specifically, focus is given on SARS-CoV-2 immunopathogenesis in the context of experimental therapies and preclinical evidence and their applicability in supporting efficacious clinical trial planning. The review discusses the existing challenges of SARS-CoV-2 diagnostics and the potential application of translational technology for epidemiological predictions, patient monitoring, and treatment decision-making in COVID-19. Furthermore, solutions for enhancing international strategies in translational research, cooperative networks, and regulatory partnerships are contemplated.

DOI: 10.1097/SHK.0000000000001565
PubMed: 32433217
PubMed Central: PMC7363382

Affiliations:

Allemagne, Autriche, France, Grèce, Hongrie, Pologne, États-Unis
Attique (région), Bade-Wurtemberg, Californie, District de Tübingen, Saxe-Anhalt, Vienne (Autriche), Île-de-France
Athènes, Magdebourg, Paris, Ulm, Vienne (Autriche)

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 001187
to stream Main, to step Curation: 001187

Le document en format XML

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<front><div type="abstract" xml:lang="en">Approximately 3 billion people around the world have gone into some form of social separation to mitigate the current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. The uncontrolled influx of patients in need of emergency care has rapidly brought several national health systems to near-collapse with deadly consequences to those afflicted by Coronavirus Disease 2019 (COVID-19) and other critical diseases associated with COVID-19. Solid scientific evidence regarding SARS-CoV-2/COVID-19 remains scarce; there is an urgent need to expand our understanding of the SARS-CoV-2 pathophysiology to facilitate precise and targeted treatments. The capacity for rapid information dissemination has emerged as a double-edged sword; the existing gap of high-quality data is frequently filled by anecdotal reports, contradictory statements, and misinformation. This review addresses several important aspects unique to the SARS-CoV-2/COVID-19 pandemic highlighting the most relevant knowledge gaps and existing windows-of-opportunity. Specifically, focus is given on SARS-CoV-2 immunopathogenesis in the context of experimental therapies and preclinical evidence and their applicability in supporting efficacious clinical trial planning. The review discusses the existing challenges of SARS-CoV-2 diagnostics and the potential application of translational technology for epidemiological predictions, patient monitoring, and treatment decision-making in COVID-19. Furthermore, solutions for enhancing international strategies in translational research, cooperative networks, and regulatory partnerships are contemplated.</div>
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<Abstract><AbstractText>Approximately 3 billion people around the world have gone into some form of social separation to mitigate the current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. The uncontrolled influx of patients in need of emergency care has rapidly brought several national health systems to near-collapse with deadly consequences to those afflicted by Coronavirus Disease 2019 (COVID-19) and other critical diseases associated with COVID-19. Solid scientific evidence regarding SARS-CoV-2/COVID-19 remains scarce; there is an urgent need to expand our understanding of the SARS-CoV-2 pathophysiology to facilitate precise and targeted treatments. The capacity for rapid information dissemination has emerged as a double-edged sword; the existing gap of high-quality data is frequently filled by anecdotal reports, contradictory statements, and misinformation. This review addresses several important aspects unique to the SARS-CoV-2/COVID-19 pandemic highlighting the most relevant knowledge gaps and existing windows-of-opportunity. Specifically, focus is given on SARS-CoV-2 immunopathogenesis in the context of experimental therapies and preclinical evidence and their applicability in supporting efficacious clinical trial planning. The review discusses the existing challenges of SARS-CoV-2 diagnostics and the potential application of translational technology for epidemiological predictions, patient monitoring, and treatment decision-making in COVID-19. Furthermore, solutions for enhancing international strategies in translational research, cooperative networks, and regulatory partnerships are contemplated.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Osuchowski</LastName>
<ForeName>Marcin F</ForeName>
<Initials>MF</Initials>
<AffiliationInfo><Affiliation>Ludwig Boltzmann Institute for Experimental and Clinical Traumatology in the AUVA Trauma Research Center, Vienna, Austria.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Aletti</LastName>
<ForeName>Federico</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Department of Bioengineering, University of California San Diego, La Jolla, California.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cavaillon</LastName>
<ForeName>Jean-Marc</ForeName>
<Initials>JM</Initials>
<AffiliationInfo><Affiliation>National Research Agency, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Flohé</LastName>
<ForeName>Stefanie B</ForeName>
<Initials>SB</Initials>
<AffiliationInfo><Affiliation>Department of Trauma, Hand, and Reconstructive Surgery, University Hospital Essen, University Duisburg-Essen, Essen, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Giamarellos-Bourboulis</LastName>
<ForeName>Evangelos J</ForeName>
<Initials>EJ</Initials>
<AffiliationInfo><Affiliation>4th Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, Athens, Greece.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Huber-Lang</LastName>
<ForeName>Markus</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Institute of Clinical and Experimental Trauma-Immunology, University Hospital Ulm, Ulm University, Ulm, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Relja</LastName>
<ForeName>Borna</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Experimental Radiology, Department of Radiology and Nuclear Medicine, Otto von Guericke University Magdeburg, Magdeburg, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Skirecki</LastName>
<ForeName>Tomasz</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Laboratory of Flow Cytometry, Centre of Postgraduate Medical Education, Warsaw, Poland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Szabó</LastName>
<ForeName>Andrea</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Institute of Surgical Research, University of Szeged, Szeged, Hungary.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Maegele</LastName>
<ForeName>Marc</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Trauma and Orthopaedic Surgery, Cologne-Merheim Medical Center (CMMC), University of Witten/Herdecke, Cologne-Merheim Campus, Cologne, Germany.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Institute for Research in Operative Medicine (IFOM), University of Witten/Herdecke, Cologne-Merheim Campus, Cologne, Germany.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D016454">Review</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Shock</MedlineTA>
<NlmUniqueID>9421564</NlmUniqueID>
<ISSNLinking>1073-2322</ISSNLinking>
</MedlineJournalInfo>
<SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName>
<SupplMeshName Type="Protocol" UI="C000657964">COVID-19 diagnostic testing</SupplMeshName>
<SupplMeshName Type="Protocol" UI="C000705127">COVID-19 drug treatment</SupplMeshName>
<SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName>
</SupplMeshList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="Y">Betacoronavirus</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D019411" MajorTopicYN="Y">Clinical Laboratory Techniques</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002986" MajorTopicYN="N">Clinical Trials as Topic</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName>
<QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName>
<QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName>
<QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName>
<QualifierName UI="Q000635" MajorTopicYN="N">transmission</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName>
<QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName>
<QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName>
<QualifierName UI="Q000635" MajorTopicYN="N">transmission</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
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<Day>21</Day>
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<Day>25</Day>
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<Minute>0</Minute>
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<PubMedPubDate PubStatus="entrez"><Year>2020</Year>
<Month>5</Month>
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<Hour>6</Hour>
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<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">32433217</ArticleId>
<ArticleId IdType="doi">10.1097/SHK.0000000000001565</ArticleId>
<ArticleId IdType="pmc">PMC7363382</ArticleId>
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<li>Autriche</li>
<li>France</li>
<li>Grèce</li>
<li>Hongrie</li>
<li>Pologne</li>
<li>États-Unis</li>
</country>
<region><li>Attique (région)</li>
<li>Bade-Wurtemberg</li>
<li>Californie</li>
<li>District de Tübingen</li>
<li>Saxe-Anhalt</li>
<li>Vienne (Autriche)</li>
<li>Île-de-France</li>
</region>
<settlement><li>Athènes</li>
<li>Magdebourg</li>
<li>Paris</li>
<li>Ulm</li>
<li>Vienne (Autriche)</li>
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<tree><country name="Autriche"><region name="Vienne (Autriche)"><name sortKey="Osuchowski, Marcin F" sort="Osuchowski, Marcin F" uniqKey="Osuchowski M" first="Marcin F" last="Osuchowski">Marcin F. Osuchowski</name>
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<country name="États-Unis"><region name="Californie"><name sortKey="Aletti, Federico" sort="Aletti, Federico" uniqKey="Aletti F" first="Federico" last="Aletti">Federico Aletti</name>
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<country name="France"><region name="Île-de-France"><name sortKey="Cavaillon, Jean Marc" sort="Cavaillon, Jean Marc" uniqKey="Cavaillon J" first="Jean-Marc" last="Cavaillon">Jean-Marc Cavaillon</name>
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<country name="Allemagne"><noRegion><name sortKey="Flohe, Stefanie B" sort="Flohe, Stefanie B" uniqKey="Flohe S" first="Stefanie B" last="Flohé">Stefanie B. Flohé</name>
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<name sortKey="Huber Lang, Markus" sort="Huber Lang, Markus" uniqKey="Huber Lang M" first="Markus" last="Huber-Lang">Markus Huber-Lang</name>
<name sortKey="Maegele, Marc" sort="Maegele, Marc" uniqKey="Maegele M" first="Marc" last="Maegele">Marc Maegele</name>
<name sortKey="Maegele, Marc" sort="Maegele, Marc" uniqKey="Maegele M" first="Marc" last="Maegele">Marc Maegele</name>
<name sortKey="Relja, Borna" sort="Relja, Borna" uniqKey="Relja B" first="Borna" last="Relja">Borna Relja</name>
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<country name="Grèce"><region name="Attique (région)"><name sortKey="Giamarellos Bourboulis, Evangelos J" sort="Giamarellos Bourboulis, Evangelos J" uniqKey="Giamarellos Bourboulis E" first="Evangelos J" last="Giamarellos-Bourboulis">Evangelos J. Giamarellos-Bourboulis</name>
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</country>
<country name="Pologne"><noRegion><name sortKey="Skirecki, Tomasz" sort="Skirecki, Tomasz" uniqKey="Skirecki T" first="Tomasz" last="Skirecki">Tomasz Skirecki</name>
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</country>
<country name="Hongrie"><noRegion><name sortKey="Szab, Andrea" sort="Szab, Andrea" uniqKey="Szab A" first="Andrea" last="Szab">Andrea Szab</name>
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Serveur d'exploration sur la COVID en France

SARS-CoV-2/COVID-19: Evolving Reality, Global Response, Knowledge Gaps, and Opportunities.

SARS-CoV-2/COVID-19: Evolving Reality, Global Response, Knowledge Gaps, and Opportunities.

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